Methotrexate induced erythema multiforme: a case report of accidental overdose




Methotrexate is the first-line treatment for rheumatoid arthritis (RA) and can be used in patients with systemic lupus erythematosus (SLE) with poor symptom control. In addition to reducing disease symptoms, methotrexate can cause a series of side effects, including erythema multiforme, which can affect oral mucosa and cause painful ulcerations. This article presents a case of a 39-year-old patient with an unconfirmed diagnosis of SLE that received a prescription of 10 capsules of methotrexate (2.5 mg) to be used orally once a week. However, the patient misunderstood the prescription and ingested the prescribed monthly dose in one week. She was hospitalized with multiple intraoral and extraoral lesions, intense pain and dysphagia. In addition to that, she could not take oral antibiotics and had difficulty ingesting solid food. During hospitalization, the patient was treated with topical medications and laser therapy for pain and other symptoms and was released after 9 days to continue outpatient treatment. This case report shows the importance of good communication between health care professional and patient, especially regarding the understanding of the drug prescription.


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How to Cite

CRUZ AC, FIDELIS YP, VIEIRA LS, FIGUEIREDO PT, DUARTE DB, LIA EN. Methotrexate induced erythema multiforme: a case report of accidental overdose. Rev Bras Farm Hosp Serv Saude [Internet]. 2021Aug.9 [cited 2022Aug.20];12(3):642. Available from: