Pharmacotherapeutic profile of compounded drugs for the treatment of coronaviruses in patients admitted to a public hospital
Objective: : To characterize the sociodemographic and hospitalization profile of patients, as well as to determine, account for and identify dosages and costs generated with compounded drugs to meet prescriptions for people hospitalized at Hospital das Clínicas of the Medical School at the University of São Paulo (Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, HCFMUSP) due to SARS-CoV-2, between April and July 2020. Methods: A retrospective cross-sectional study of the use of compounded drugs by patients hospitalized due to coronavirus at the HCFMUSP Central Institute from April to July 2020. Personalized compounded drugs or those produced by the semi-industrial sector of the HCFMUSP Pharmacotechnics Unit were excluded from the study. The variables were presented as mean and standard deviation or proportion. Univariate statistical analysis, one-way ANOVA using Tukey as post-hoc test were applied to compare the manipulated production in the study period and the same period of 2019.3 Results: It was shown that a total of 39 standardized compounded drugs were prescribed for a total of 1,557 patients with coronavirus confirmation. Of the total number of prescription drugs, 11 drugs showed a significant increase in production in 2020, namely: furosemide (48.8 ± 17.1, p<0.004); amiodarone (50.0 ± 17.4, p<0.005); amlodipine (70.3 ± 14.4, p<0.003); hydralazine (82.8 ± 22.3, p<0.038); diazepam (95.8 ± 53.4, p<0.037); artificial saliva (146.0 ± 50.6, p<0.004); propantheline gel(155.0 ± 33.9, p<0.042); methadone (174.5 ± 45.2, p<0.002); hydrochlorothiazide (204.5 ± 46.4, p<0.001); omeprazole (537.5 ± 194.8, p<0.031) and quetiapine (597.0 ± 116.3, p<0.000). Omeprazole and quetiapine were the most prescribed products for hospitalized patients. The estimated total cost of meeting prescriptions during the study period was $20,854.01. Conclusions: The manipulated drugs provided mechanically ventilated patients with adequate pharmacotherapy and facilitated the process of weaning from sedation. The institution obtained a reduction in cost due to the manipulated product presenting a better cost-effect ratio when compared to injectable forms of medication.
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