Characterization of potential drug interactions with antimicrobials in a pediatric intensive care unit, Western Amazon

Authors

  • Francimar L. JUCÁ
  • Andreia F. BRILHANTE
  • Leonardo K. MELCHIOR
  • Sammuel C. PINHEIRO
  • Suyane G. BRAGA

DOI:

https://doi.org/10.30968/rbfhss.2022.134.0733

Abstract

Objective: Characterize the occurrence of potential drug interactions (PDIs) involving antimicrobials in a pediatric intensive care unit (PICU) in Acre state, Western Amazon. Methods: The cross-sectional study analyzed 246 prescriptions from patients up to 11 years old, made in the first 24 hours of hospitalization. Consultations about PDIs were made using Truven Health Analytics Micromedex® Solutions 2.0. classifying according to severity. Results: In the 246 prescriptions analyzed, 28 types of antimicrobials were found, the most prescribed were: ceftriaxone 32.7% (n = 123) and ampicillin 9.3% (n = 35). When analyzing in Micromedex® the information about all the drugs prescribed in this sample, it was obtained in 56% (n = 139) of the prescriptions, 435 PDIs of 64 different types, already described in the literature involving only antimicrobials and antimicrobials with other groups of drugs. Among antimicrobials, ampicillin 28% (n = 26) and gentamicin 23.7% (n = 22) were the most often related to PDIs and in 54.7% (n = 238), the severity of these PDIs it was moderate. Conclusion: We conclude that the PDIs found in the PICU, although well documented, are of serious concern due to their potential effects. The results presented stimulate actions that can guarantee greater safety for hospitalized pediatric patients.

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References

Food and Drug Administration (FDA). Council on Family Health. Drug Interactions: What You Should Know? Estados Unidos: Council on Family Health, National Consumers League and the U.S. Food and Drug Administration, 2004. Available in: https://www.fda.gov/media. Accessed on November 13th 2019.

Secoli SR. Interações medicamentosas: fundamentos para a prática clínica da enfermagem. Rev Esc Enferm (USP). 2001;35(1):28-34. DOI: https://doi.org/10.1590/S0080-62342001000100005

Reis AM, Cassiani SH. Prevalence of potential drug interactions in patients in an intensive care unit of a university hospital in Brazil. Clinics. 2011;66(1):9-15. doi: https://doi.org/10.1590/s1807-59322011000100003

Rodrigues AT, Stahlschmidt R, Granja S, Pilger D, Falcão ALE, Mazzola PG. Prevalence of potential drug-drug interactions in the intensive care unit of a Brazilian teaching hospital. Braz J Pharm Sci. 2017;53(1): e16109. DOI: https://doi.org/10.1590/s2175-97902017000116109

Hinrichsen SL, Santos C, Diniz T et al. Infecções em UTI. In: Hinrichsen SL. Doenças infecciosas e parasitárias. Rio de Janeiro: MEDSI; Guanabara Koogan; 2005. p. 988-1031.

Rodrigues FA, Bertoldi AD. Perfil da utilização de antimicrobianos em um hospital privado. Ciênc Saude Colet. 2010;15(Supl. 1):1239-1247. DOI: https://doi.org/10.1590/S1413-81232010000700033

IBGE. Instituto Brasileira de Geografia e Estatística. Available in: https://cidades.ibge.gov.br/brasil/ac/rio-branco . Accessed on October 25th 2019.

ANVISA. Agência Nacional de Vigilância Sanitária. Resolução nº 7 de 24 de fevereiro de 2010. Ministério da Saúde, Brasília-DF, 2010.

Kearns GL, Abdel-Rahman SM, Alander SW et al. Developmental pharmacology-drug disposition, action, and therapy in infants and children. N Engl J Med. 2003;349(12):1157-67. DOI: https://doi.org/10.1056/NEJMra035092

Pereira, JCR. Bioestatística em outras palavras. São Paulo: Editora Universidade de São Paulo, Fapesp, 2010.

Mascha EJ, Vetter TR. Significance, Errors, Power, and Sample Size: The Blocking and Tackling of Statistics. Anesth Analg. 2018;126(2):691-698. Doi: https://doi.org/10.1213/ANE.0000000000002741

EPI Info™ 7 Version 7.1.4. Atlanta: Centers for Disease Control and Prevention; 2014. Available in: http://www.cdc.gov/epiinfo Accessed on October 15th 2016.

Micromedex® Solutions. Interações medicamentosas. Canadá. 2016. Available in:http://www.micromedexsolutionscom.ez67.periodicos.capes.gov.br/micromedex2/librarian Accessed on October 30th 2016.

IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.

Marques CRP, Leão NML, Sousa SF et al. Interações Medicamentosas na Unidade de Terapia Intensiva de um Hospital de Referência no Sul do Tocantins – Brasil. Cereus. 2018;10(3):17-26.

Paiva NA, Moura CS. Interações Medicamentosas Potenciais nas Prescrições de Pacientes Pediátricos Hospitalizados. Ver Bras Farm 2012; 93(4): 463-468.

Cortes ALB, Silvino ZR. Factors associated to potential drug interactions in one Intensive Care Unit: a cross-sectional study. Esc Anna Nery 2019; 23(3):2018. DOI: https://doi.org/10.1590/2177-9465-EAN-2018-0326

Frederico PM. Interações medicamentosas potenciais dos anti-hipertensivos: uso perigoso em idosos [Master’s thesis]. Escola Nacional de Saúde Pública da Fundação Osvaldo Cruz, Rio de Janeiro, 2012.

Martinbiancho J, Zuckerman J, Santos L et al. Profile of drug interactions in hospitalized children. Pharm Pract. 2007;5(4):157-61.

Cedraz KN, Santos Junior MC. Identificação e caracterização de interações medicamentosas em prescrições médicas da unidade de terapia intensiva de um hospital público da cidade de Feira de Santana, BA. Rev Soc Bras Clin Med. 2014;12(2):1-7.

Piedade DV, Silva LAF, Lemos GS et al. Interações medicamentosas potenciais em prescrições, contendo antimicrobianos de uso restrito, de pacientes internados em um hospital no interior da Bahia. Medicina. 2015;48(3):295-307.

Queiroz KCB, Nascimento MFS, Fernandes V et al. Drug interactions on the neonatal prescription at ICU-HGU. Cient Ciênc Biol Saúde. 2014;16(3):203-7.

Calil R, Caldas JPS. Uso racional e seguro de antibióticos em neonatologia. 2012. Available in: http://www.sbp.com.br/pdfs/USO_RACIONAL_SEGURO_ANTIBIOTICOS_NEONATOLOGIA2.pdf Accessed on October 1st 2016.

Instituto para Práticas Seguras no Uso de Medicamentos. Available in: https://www.ismp-brasil.org/site/ Accessed on October 1st 2016.

Oliveira TF, Lima-Dellamora EC. Interações potencialmente perigosas: proposta de uma lista de referência para pediatria. Rev Bras Farm Hosp Serv Saúde. 2013;3(4):17-23.

Lima REF, Cassiani SHB. Potential drug interactions in intensive care patients at a teaching hospital. Rev Latino-Am Enfermagem. 2009;17(2):222-7. DOI: https://doi.org/10.1590/S0104-11692009000200013

Lima EC, Vieira JM, Alves IC, Cabral LM, Turner MA. Suspected adverse Drug reactions reported for Brazilian children: cross-sectional study. J Pediatr. 2019;95:682-8. DOI: https://doi.org/10.1016/j.jped.2018.05.019.

Published

2022-12-01

How to Cite

1.
JUCÁ FL, BRILHANTE AF, MELCHIOR LK, PINHEIRO SC, BRAGA SG. Characterization of potential drug interactions with antimicrobials in a pediatric intensive care unit, Western Amazon. Rev Bras Farm Hosp Serv Saude [Internet]. 2022Dec.1 [cited 2024Mar.29];13(4):733. Available from: https://www.rbfhss.org.br/sbrafh/article/view/733

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Section

ORIGINAL ARTICLES